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KMID : 0895820070170010001
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Journal of Oriental Rehabilitation Medicine
2007 Volume.17 No. 1 p.1 ~ p.16
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Effects of Neutral Eohyeol(Yuxue) Herbal Acupuncture and Dangkisoo-san(Dangguixu-san) on Fracture Healing in the Early Stage in Rats
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An Hye-Lim
Choi Jin-Bong
Kim Sun-Jong
Shin Mi-Suk
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Abstract
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Objectives: This study was designed to evaluate the effects of Neutral Eohyeol(Yuxue) herbal acupuncture and Dangkisoo-san(Dangguixu-san) on fracture healing in rats.
Methods: We divided the subjects into 5 groups : normal, control with no treatment, Sample Ⅰ taken with Dangkisoo-san(Dangguixu-san), Sample Ⅱ taken with Neutral Eohyeol(Yuxue) herbal acupuncture and sample Ⅲ taken with Neutral Eohyeol(Yuxue) herbal acupuncture and Dangkisoo-san(Dangguixu-san) groups. We induced penetrating fracture on femur in control, sample Ⅰ, Ⅱ and Ⅲ groups. And after serum T-ALP, serum osteocalcin, histological changes, and the degree of TGF-β1 in each group were observed at the 7th day and at the 14th day respectively.
Results: All the sample groups showed significant changes in serum T-ALP, histological observation and TGF-beta 1 compared with control group. Especially sample Ⅲ was more effective than other groups in fracture healing. However, serum osteocalcin insignificantly increased at the 14th day. It seemed that 14 day was too short to evaluate osteocalcin.
Conclusions: It is suggested that Neutral Eohyeol(Yuxue) herbal acupuncture and Dangkisoo-san(Dangguixu-san) may play a significant role in fracture healing and these two treatments could be more effective when used together.
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KEYWORD
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Neutral Eohyeol(Yuxue) herbal acupuncture, Dangkisoo-san(Dangguisu-san), Fracture
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